Isaiah,

For e-mailing and auto-responders, I recommend 1-2-All by Active Campaign. I've set up a # of my hosting clients with their own stand-alone installations, and I also run a shared install for smaller Mom & Pop type businesses who run smaller lists. 1-2-All does scheduled mailings, stacked/series of messages each of which you can schedule, runs ordinary mailing lists, the whole 9 yards. Has click-through tracking/stats and LOTS more. It is very effective for the price and the only ongoing fees are your own hosting account.

Just make sure that you host on clean IP space, your host allows the volume of e-mail you are sending out, and that your mailing practices are reputable so that you don't end up with spam complaints. There is nothing that will make your day more miserable more quickly than to break net etiquette and create a spam/UBE mess. If you use a reputable host w/ clean IP space, and use reputable mailing practices yourself, you won't have any problems running your own list.

Bailey